1. Install the Microsoft Fonts using this command:

sudo apt install ttf-mscorefonts-installer -y

2. Create the following directory and the fonts.conf file:

mkdir -p ~/.config/fontconfig/

then

vim ~/.config/fontconfig/fonts.conf

now paste this setting:

<?xml version='1.0'?>
<!DOCTYPE fontconfig SYSTEM 'fonts.dtd'>
<fontconfig>
<match target="font">
    <edit mode="assign" name="antialias">
        <bool>true</bool>
    </edit>
    <edit mode="assign" name="embeddedbitmap">
        <bool>false</bool>
    </edit>
    <edit mode="assign" name="hinting">
        <bool>true</bool>
    </edit>
    <edit mode="assign" name="hintstyle">
        <const>hintslight</const>
    </edit>
    <edit mode="assign" name="lcdfilter">
        <const>lcddefault</const>
    </edit>
    <edit mode="assign" name="rgba">
        <const>rgb</const>
    </edit>
</match>
</fontconfig>

3. Run these commmands:

# Reconfigure fontconfig
sudo dpkg-reconfigure fontconfig-config

# Regenerate fonts cache
sudo dpkg-reconfigure fontconfig

Or just run

sudo fc-cache -fv

4. Reboot your PC.

sudo reboot

5. Open GNOME Tweaks and set the following:

Interface Text: Ubuntu
Document Text: Ubuntu
Monospace Text: MesloLGS NF (or any of the ttf-meslo-nerd)
    
Rendering (Hinting):
        
Slight

Antialiasing:

Subpixel (for LCD screens)

Using the FREETYPE_PROPERTIES option for bolder fonts (less pixelated, more like Windows TrueType):

  1. Enter the following command in the terminal: 
    sudo vim /etc/environment
  2. Copy and paste the following: 
    # Better font rendering
FREETYPE_PROPERTIES="cff:no-stem-darkening=0 autofitter:no-stem-darkening=0"
  3. Save the changes and reboot the machine

Quick Note

I highly recommend you check out the Debian Post Install guide first If you haven’t yet.